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Ask the Experts: DAXXIFY vs. BOTOX

Karli Plunkett, DMSc, PA-C, LME

August 22, 2023

3 min read

daxxify vs botox cost

In the realm of cosmetic enhancements, the landscape is ever-changing. With a plethora of injectables available, the decision-making process can be overwhelming. Two of the most discussed contenders in this arena are Botox and Daxxify. While both are well-established for their wrinkle-reducing prowess, discerning their differences is crucial. We use both neuromodulators on a daily basis with our patients, and have found there is plenty to learn from both the research and actual patient experiences to get to the bottom of comparing Botox vs. Daxxify.

What are Daxxify and Botox?

Botox and Daxxify are both forms of botulinum toxin type A, designed to temporarily paralyze target muscles, reducing the appearance of fine lines and wrinkles. This results in a smoother, more youthful complexion. While Botox has been a household name for years, Daxxify is a newer entrant, boasting unique peptide exchange technology.

What is Daxxify?

Daxxify, scientifically known as daxibotulinumtoxina-lanm, is a groundbreaking neuromodulator birthed by Revance Therapeutics. It has garnered FDA approval for its efficacy in treating glabellar lines or the frown wrinkles that many are familiar with. What makes Daxxify stand out is its formulation. Unlike other products in its category, Daxxify is formulated without any human or animal derivatives, thanks to its pioneering peptide technology. This not only ensures unparalleled stability but also results in effects that last significantly longer at the neuromuscular junction.

What is Botox?

Botox has been a household name since its introduction in 2002. Its primary function is to temporarily paralyze muscles, leading to a noticeable reduction in facial wrinkles and lines. Its precision in targeting specific areas, such as crow's feet and frown lines, has solidified its position as a favorite among many seeking cosmetic enhancements.

What's the Difference Between Daxxify vs. Botox?

  1. Duration of Effect: One of the most prominent differences between Daxxify and Botox is their longevity. While Botox's effects typically last between three to four months, Daxxify has been shown to last an average of six months. Some users have even reported effects lasting up to nine months. This extended duration translates to fewer treatments annually for those opting for Daxxify.

  2. Neuromodulator Formulation: Daxxify's peptide exchange technology is a game-changer. This unique formulation allows it to remain stable without the need for human or animal products, contributing to its extended duration of effect.

  3. Onset of Results: Both Botox and Daxxify begin to show results relatively quickly. In Daxxify trials, a majority of patients observed full results within two weeks, with a median time to onset of a clinically meaningful response at three days. This is comparable to the onset time of Botox.

Is Daxxify more expensive than Botox?

While both Daxxify and Botox are leading cosmetic treatments, their cost structures differ. Daxxify units are priced between $15 and $25, above Botox's $10 to $15 range. Our Orlando patients pay $11-13 per unit for Botox (depending upon their membership status) and $12-14 per unit for Daxxify. We also offer patients their first Daxxify treatment at Botox pricing. 


Daxxify's longer-lasting effects, which can span up to six months, mean fewer annual treatments and potentially lower yearly expenses. The treatment area and dosage also influence cost; certain regions might need more units of one product over the other. Additionally, prices can vary based on the provider's expertise and clinic location. While Daxxify has a steeper unit price, its extended duration might offer better value over time. It's essential to consider both immediate costs and long-term expenditures, factoring in treatment frequency and provider charges, to determine the most cost-effective choice.

Which Injectable Neuromodulator is Right for Me?

The choice between Botox and Daxxify boils down to individual preferences and specific needs. If you prioritize longevity, Daxxify might be the superior choice. However, for those new to the world of injectables, starting with a shorter-lasting option like Botox might be advisable. It's paramount to consult with a qualified provider to assess your unique needs and recommend the best treatment tailored for you. Remember, these treatments aren't permanent and require periodic maintenance to sustain their effects. 


Navigating the world of cosmetic treatments can be a maze. However, with the right information, making an informed decision becomes easier. Daxxify, with its innovative formulation and longer-lasting effects, offers a promising alternative to traditional treatments. On the other hand, Botox, with its precision and long-standing reputation, remains a top choice for many. Both have their unique strengths, and the decision ultimately hinges on individual needs and preferences. Always prioritize professional consultation to ensure you're well-informed about potential risks and benefits.

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